Our Reviews

Our Reviews

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(1→3)-β-D-glucan testing for the detection of invasive fungal infections in immunocompromised or critically ill people

(Reishi mushroom) for cancer treatment

Acupuncture for insomnia in people with cancer

Adjuvant (post-surgery) chemotherapy for early stage epithelial ovarian cancer

Adjuvant chemotherapy after concurrent chemoradiation for locally advanced cervical cancer

Adjuvant chemotherapy for advanced endometrial cancer

Adjuvant chemotherapy for endometrial cancer after hysterectomy

Adjuvant chemotherapy for localised resectable soft tissue sarcoma in adults

Adjuvant gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in premenopausal women

Adjuvant platinum-based chemotherapy for early stage cervical cancer

Adjuvant progestagens for endometrial cancer

Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma

Adjuvant radiotherapy for inguinal lymph node metastases following surgery for vulval cancer

Adjuvant radiotherapy for stage I endometrial cancer

Adjuvant treatment after hysterectomy for uterine leiomyosarcoma

Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas

Amphotericin B lipid soluble formulations versus amphotericin B in cancer patients with neutropenia

Amphotericin B versus fluconazole for controlling fungal infections in neutropenic cancer patients

Angiogenesis inhibitors for the treatment of ovarian cancer

Anti-angiogenic therapy for high-grade glioma

Anti-epidermal growth factor receptor therapy for glioblastoma in adults

Anti-pseudomonal beta-lactams for the initial, empirical, treatment of febrile neutropenia: comparison of beta-lactams

Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy

Antibiotics for infection prevention after excision of the cervical transformation zone

Anticoagulation for people with cancer and central venous catheters

Anticoagulation for perioperative thromboprophylaxis in people with cancer

Anticoagulation for the initial treatment of venous thromboembolism in people with cancer

Anticoagulation for the long-term treatment of venous thromboembolism in people with cancer

Antidepressants for the treatment of depression in people with cancer

Antifungal therapy in infants and children with proven, probable or suspected invasive fungal infections

Antigen-specific active immunotherapy for ovarian cancer

Antithrombotic therapy for ambulatory patients with multiple myeloma receiving immunomodulatory agents

Autologous hematopoietic stem cell transplantation following high-dose chemotherapy for nonrhabdomyosarcoma soft tissue sarcomas

Beta-lactam versus beta-lactam-aminoglycoside combination therapy in cancer patients with neutropenia

Biopsy versus resection for high-grade glioma

Biopsy versus resection for the management of low-grade gliomas

Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy

Cardioprotective interventions for cancer patients receiving anthracyclines

Centralisation of services for gynaecological cancer

Chemoradiation for advanced primary vulval cancer

Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma

Chemotherapy for advanced ovarian cancer

Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma

Chemotherapy for high-grade glioma

Chemotherapy for malignant germ cell ovarian cancer in adult patients with early stage, advanced and recurrent disease

Chemotherapy for metastatic and recurrent cervical cancer

Chemotherapy for resistant or recurrent gestational trophoblastic neoplasia

Chemotherapy for thymic carcinoma and advanced thymoma in adults

Chemotherapy wafers for high grade glioma

Cognitive behavioural therapy for insomnia in people with cancer

Collection devices for obtaining cervical cytology samples

Colony-stimulating factors for chemotherapy-induced febrile neutropenia

Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour

Combined use of hyperthermia and (chemo)radiation therapy for treating locally advanced cervix carcinoma

Communication skills training for healthcare professionals working with people who have cancer

Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV-related disease in females and males

Concomitant chemotherapy and radiation therapy for cancer of the uterine cervix

Concomitant hydroxyurea plus radiotherapy versus radiotherapy for carcinoma of the uterine cervix

Couple-based interventions for improving dyadic adjustment in people with cancer and their spousal partners

Cytology for the diagnosis of endometrial cancer in symptomatic women

Cytology versus HPV testing for cervical cancer screening in the general population

Cytoreductive surgery plus chemotherapy versus chemotherapy alone for recurrent epithelial ovarian cancer

Dance/movement therapy for improving psychological and physical outcomes in cancer patients

Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer

Dexrazoxane for preventing or reducing cardiotoxicity in adults and children with cancer receiving anthracyclines

Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma

Dietary interventions for adult cancer survivors

Different anthracycline derivates for reducing cardiotoxicity in cancer patients

Different dosage schedules for reducing cardiotoxicity in people with cancer receiving anthracycline chemotherapy

Doxorubicin-based chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft tissue sarcoma

Early discontinuation of antibiotics for febrile neutropenia versus continuation until neutropenia resolution in people with cancer

Early palliative interventions for improving outcomes in people with a primary malignant brain tumour and their carers

Early surgical treatment versus observational management for cervical intraepithelial neoplasia 2 (CIN2)

Early versus delayed postoperative radiotherapy for treatment of low-grade gliomas

Effectiveness of different treatment modalities for the management of adult-onset granulosa cell tumours of the ovary (primary and recurrent)

Effectiveness of tranexamic acid in reducing blood loss during cytoreductive surgery for advanced ovarian cancer

Effects of different weight loss programmes on oncological outcomes following curative resection of digestive tract cancers

Effects of human papillomavirus (HPV) vaccination programmes on community rates of HPV-related disease and harms from vaccination

Electric fans for reducing adverse health impacts in heatwaves

Empirical antibiotics targeting gram-positive bacteria for the treatment of febrile neutropenic patients with cancer

Epidermal growth factor receptor blockers for the treatment of ovarian cancer

Evaluation of follow-up strategies for patients with epithelial ovarian cancer following completion of primary treatment

Exenterative surgery for recurrent gynaecological malignancies

Exercise for fatigue in people with cancer during and after active treatment

Exercise interventions for adults with cancer receiving radiation therapy alone

Exercise interventions for people undergoing multimodal cancer treatment that includes surgery

Exercise interventions on health-related quality of life for cancer survivors

Exercise interventions on health-related quality of life for people with cancer during active treatment

Extended-field radiotherapy for locally advanced cervical cancer

External beam radiation dose escalation for high grade glioma

Fertility and early pregnancy outcomes after conservative treatment for cervical intraepithelial neoplasia

Fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer

Fertility-sparing, surgical interventions for low-risk, non-metastatic gestational trophoblastic neoplasia

First- and second-line systemic treatments for metastatic and locally advanced soft tissue sarcomas in adults

First-line chemotherapy in low-risk gestational trophoblastic neoplasia

First-line treatments for people with single or multiple brain metastases

Follow-up protocols for women with cervical cancer after primary treatment

Follow-up strategies after treatment (large loop excision of the transformation zone (LLETZ)) for cervical intraepithelial neoplasia (CIN): Impact of human papillomavirus (HPV) test

Follow-up strategies for women with endometrial cancer after primary treatment

Gemcitabine for platinum-resistant or recurrent ovarian cancer

Ginseng for improving the quality of life in people with cancer

Granulocyte transfusions for preventing infections in people with neutropenia or neutrophil dysfunction

Granulocyte transfusions for treating infections in people with neutropenia or neutrophil dysfunction

Green tea (Camellia sinensis) for the prevention of cancer

Health education interventions to promote early presentation and referral for women with symptoms of endometrial cancer

High dose rate versus low dose rate intracavity brachytherapy for locally advanced uterine cervix cancer

Home parenteral nutrition for people with inoperable malignant bowel obstruction

Hormonal therapy in advanced or recurrent endometrial cancer

Hormone replacement therapy after surgery for epithelial ovarian cancer

Hormone replacement therapy for women previously treated for endometrial cancer

Human papillomavirus (HPV) vaccination for the prevention of cervical cancer and other HPV-related diseases: a network meta-analysis

Human papillomavirus testing versus repeat cytology for triage of minor cytological cervical lesions

Hyperbaric oxygen therapy for late radiation tissue injury

Hyperbaric oxygenation for tumour sensitisation to radiotherapy

Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer

Image guided surgery for the resection of brain tumours

Immediate referral to colposcopy versus cytological surveillance for minor cervical cytological abnormalities in the absence of HPV test

Immune checkpoint blockade for glioma

Immunotherapy for intracranial metastatic melanoma

Impact of epithelial ovarian cancer screening on patient-relevant outcomes in average-risk postmenopausal women

Impact of ovarian preservation on survival for women with endometrial carcinoma

Impact of residual disease as a prognostic factor for survival in women with advanced epithelial ovarian cancer after primary surgery

Influenza vaccines in immunosuppressed adults with cancer

Interferon after surgery for women with advanced (Stage II-IV) epithelial ovarian cancer

Interval brain imaging for adults with cerebral glioma

Interval debulking surgery for advanced epithelial ovarian cancer

Interventions for encouraging sexual behaviours intended to prevent cervical cancer

Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation

Interventions for preventing blood loss during the treatment of cervical intraepithelial neoplasia

Interventions for promoting habitual exercise in people living with and beyond cancer

Interventions for psychosexual dysfunction in women treated for gynaecological malignancy

Interventions for reducing anxiety in women undergoing colposcopy

Interventions for the management of fatigue in adults with a primary brain tumour

Interventions for the physical aspects of sexual dysfunction in women following pelvic radiotherapy

Interventions for the treatment of borderline ovarian tumours

Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery

Interventions for the treatment of Paget's disease of the vulva

Interventions for weight reduction in obesity to improve survival in women with endometrial cancer

Interventions targeted at women to encourage the uptake of cervical screening

Interventions to help support caregivers of people with a brain or spinal cord tumour

Interventions to improve insulin resistance for the prevention of endometrial cancer

Interventions to improve psychosexual function in women treated for gynaecological cancers

Interventions to improve psychosocial well-being in female BRCA-mutation carriers following risk-reducing surgery

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic cancers

Interventions to reduce the time to diagnosis of brain tumours

Intralesional treatment versus wide resection for central low-grade chondrosarcoma of the long bones

Intraoperative frozen section analysis for the diagnosis of early stage ovarian cancer in suspicious pelvic masses

Intraoperative imaging technology to maximise extent of resection for glioma

Intraoperative imaging technology to maximise extent of resection for glioma: a network meta-analysis

Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer

Ketogenic diet for primary brain and spinal cord tumours

Laetrile treatment for cancer

Laparoscopically assisted radical vaginal hysterectomy versus radical abdominal hysterectomy for the treatment of early cervical cancer

Laparoscopy for diagnosing resectability of disease in women with advanced ovarian cancer

Laparoscopy versus laparotomy for FIGO stage I ovarian cancer

Laparoscopy versus laparotomy for the management of early stage endometrial cancer

Long-term neurocognitive and other side effects of radiotherapy, with or without chemotherapy, for glioma

Low cost versus other screening tests to detect cervical cancer or precancer in developing countries

Luteinising hormone releasing hormone (LHRH) agonists for the treatment of relapsed epithelial ovarian cancer

Lymph node dissection (lymphadenectomy) for presumed early stage epithelial ovarian cancer

Lymphadenectomy for the management of endometrial cancer

Magnetic resonance perfusion for differentiating low-grade from high-grade gliomas at first presentation

Maintenance chemotherapy for ovarian cancer

Management of drainage for malignant ascites in gynaecological cancer

Medical and surgical interventions for the treatment of usual-type vulval intraepithelial neoplasia

Medical interventions for high-grade vulval intraepithelial neoplasia

Menopausal status, ultrasound and biomarker tests in combination for the diagnosis of ovarian cancer in symptomatic women

Minimally invasive surgery (robotic or laparoscopic) versus laparotomy for advanced ovarian cancer

Mistletoe extracts for cancer treatment

Mistletoe therapy in oncology

Moxibustion for alleviating side effects of chemotherapy or radiotherapy in people with cancer

Multidimensional rehabilitation programmes for adult cancer survivors

Music interventions for improving psychological and physical outcomes in people with cancer

Neoadjuvant chemotherapy and surgery versus chemoradiotherapy for locally advanced cervical cancer

Neoadjuvant chemotherapy before surgery versus surgery followed by chemotherapy for initial treatment in advanced ovarian epithelial cancer

Neoadjuvant chemotherapy for locally advanced cervix cancer

Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer

Nerve-sparing radical hysterectomy compared to standard radical hysterectomy for women with early stage cervical cancer (stage Ia2 to IIa)

Next-generation sequencing for guiding matched targeted therapies in people with relapsed or metastatic cancer

Non-pharmacological interventions for cognitive impairment due to systemic cancer treatment

Non-steroidal anti-inflammatory agents to induce regression and prevent the progression of cervical intraepithelial neoplasia

Non-surgical interventions for late radiation cystitis in patients who have received radical radiotherapy to the pelvis

Non-surgical interventions for late rectal problems (proctopathy) of radiotherapy in people who have received radiotherapy to the pelvis

Nutritional interventions for reducing gastrointestinal toxicity in adults undergoing radical pelvic radiotherapy

Nystatin prophylaxis and treatment in severely immunodepressed patients

Obstetric outcomes after conservative treatment for cervical intraepithelial lesions and early invasive disease

Optimal primary surgical treatment for advanced epithelial ovarian cancer

Oral anticoagulation in people with cancer who have no therapeutic or prophylactic indication for anticoagulation

Oral etoposide for treatment and/or maintenance treatment of recurrent epithelial ovarian cancer

Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients

Outpatient treatment for people with cancer who develop a low-risk febrile neutropaenic event

Pain relief for women with cervical intraepithelial neoplasia undergoing colposcopy treatment

Palliative interventions for controlling vaginal bleeding in advanced cervical cancer

Palliative surgery versus medical management for bowel obstruction in ovarian cancer

Parenteral anticoagulation in ambulatory patients with cancer

Patient-reported outcome measures for follow-up after gynaecological cancer treatment

Pegylated liposomal doxorubicin for first-line treatment of epithelial ovarian cancer

Pegylated liposomal doxorubicin for relapsed epithelial ovarian cancer

Pentoxifylline and vitamin E alone or in combination for preventing and treating side effects of radiation therapy and concomitant chemoradiotherapy

Perioperative enhanced recovery programmes for women with gynaecological cancers

Perioperative nutrition interventions for women with ovarian cancer

Pharmacological interventions for the prevention of insufficiency fractures and avascular necrosis associated with pelvic radiotherapy in adults

Pharmacological treatment of depression in people with a primary brain tumour

PI3K/AKT/mTOR inhibitors for advanced or recurrent endometrial cancer

Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer

Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised people

Positron emission tomography (PET) and magnetic resonance imaging (MRI) for assessing tumour resectability in advanced epithelial ovarian/fallopian tube/primary peritoneal cancer

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early-stage cervical cancer

Pre-emptive antifungal therapy versus empirical antifungal therapy for febrile neutropenia in people with cancer

Pre-treatment surgical para-aortic lymph node assessment in locally advanced cervical cancer

Primary groin irradiation versus primary groin surgery for early vulvar cancer

Primary surgery versus primary radiotherapy with or without chemotherapy for early adenocarcinoma of the uterine cervix

Probiotics for the prevention or treatment of chemotherapy- or radiotherapy-related diarrhoea in people with cancer

Procarbazine, lomustine and vincristine for recurrent high-grade glioma

Prognostic models for predicting recurrence and survival in women with endometrial cancer

Prognostic value of test(s) for O6-methylguanine–DNA methyltransferase (MGMT) promoter methylation for predicting overall survival in people with glioblastoma treated with temozolomide

Prophylactic antibiotics for preventing gram-positive infections associated with long-term central venous catheters in adults and children receiving treatment for cancer

Prophylactic chemotherapy for hydatidiform mole to prevent gestational trophoblastic neoplasia

Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors

Prophylaxis for Pneumocystis pneumonia (PCP) in non-HIV immunocompromised patients

Protons versus photons for the treatment of chordoma

Psychosocial interventions to improve quality of life and emotional wellbeing for recently diagnosed cancer patients

Radiotherapy and chemoradiation after surgery for early cervical cancer

Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: individual patient data meta-analysis

Retinoids for preventing the progression of cervical intra-epithelial neoplasia

Retroperitoneal drainage versus no drainage after pelvic lymphadenectomy for the prevention of lymphocyst formation in women with gynaecological malignancies

Risk of endometrial cancer in women treated with ovary-stimulating drugs for subfertility

Risk of ovarian cancer in women treated with ovarian stimulating drugs for infertility

Risk-reducing bilateral salpingo-oophorectomy in women with BRCA1 or BRCA2 mutations

Robot-assisted surgery in gynaecology

Routine versus selective antifungal administration for control of fungal infections in patients with cancer

Screening tests for endometrial cancer in the general population

Selenium for preventing cancer

Sentinel node assessment for diagnosis of groin lymph node involvement in vulval cancer

Sentinel node biopsy for diagnosis of lymph node involvement in endometrial cancer

Sentinel node biopsy for diagnosis of pelvic lymph node involvement in early stage cervical cancer

Short versus long duration infusions of paclitaxel for any advanced adenocarcinoma

Simple versus radical hysterectomy with pelvic lymphadenectomy for women with stage IA2-IB1 cervical cancer

Site-speciﬁc chemotherapy based on gene expression proﬁling versus empirical chemotherapy for people with cancer of unknown primary site

Spiritual and religious interventions for adults with cancer and their carers: an overview of systematic reviews

Surgery for cervical intraepithelial neoplasia

Surgery or radiosurgery plus whole brain radiotherapy versus surgery or radiosurgery alone for brain metastases

Surgery versus stereotactic radiotherapy for people with single or solitary brain metastasis

Surgical cytoreduction for recurrent epithelial ovarian cancer

Surgical interventions for early squamous cell carcinoma of the vulva

Surgical interventions for high-grade vulval intraepithelial neoplasia

Surgical resection and whole brain radiation therapy versus whole brain radiation therapy alone for single brain metastases

Surgical treatment of stage IA2 cervical cancer

Systematic screening and assessment of psychosocial well-being and care needs of people with cancer

Tamoxifen and aromatase inhibitors for relapse of tubo-ovarian high-grade serous cancer

Tamoxifen for relapse of ovarian cancer

Taxane monotherapy regimens for the treatment of recurrent epithelial ovarian cancer

Telephone interventions for symptom management in adults with cancer

Temozolomide for high grade glioma

Thalidomide for managing cancer cachexia

Thymic peptides for treatment of cancer patients

Topotecan for ovarian cancer

Treatment for gastrointestinal and pancreatic neuroendocrine tumours: a network meta-analysis

Treatment of newly diagnosed glioblastoma in the elderly: a network meta-analysis

Treatment options for progression or recurrence of glioblastoma: a network meta-analysis

Type II or type III radical hysterectomy compared to chemoradiotherapy as a primary intervention for stage IB2 cervical cancer

Ultra-radical (extensive) surgery versus standard surgery for the primary cytoreduction of advanced epithelial ovarian cancer

Vaginal dilator therapy for women receiving pelvic radiotherapy

Vascular endothelial growth factor (VEGF) inhibitors for the treatment of metastatic and recurrent cervical cancer

Vascular endothelial growth factor (VEGF) targeting therapy for persistent, recurrent, or metastatic cervical cancer

Voriconazole versus amphotericin B or fluconazole in cancer patients with neutropenia

Weekly versus tri-weekly paclitaxel with carboplatin for first-line treatment in women with epithelial ovarian cancer

Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases

By subtopic:

CANCER OF THE UTERINE CERVIX (52)

Follow-up strategies after treatment (large loop excision of the transformation zone (LLETZ)) for cervical intraepithelial neoplasia (CIN): Impact of human papillomavirus (HPV) test

Human papillomavirus testing versus repeat cytology for triage of minor cytological cervical lesions

Vascular endothelial growth factor (VEGF) targeting therapy for persistent, recurrent, or metastatic cervical cancer

Low cost versus other screening tests to detect cervical cancer or precancer in developing countries (protocol stage)

Sentinel node biopsy for diagnosis of pelvic lymph node involvement in early stage cervical cancer (protocol stage)

Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV-related disease in females and males

Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors

Human papillomavirus (HPV) vaccination for the prevention of cervical cancer and other HPV-related diseases: a network meta-analysis (protocol stage)

Interventions for encouraging sexual behaviours intended to prevent cervical cancer

Immunisation strategies (HPV) to prevent cervical cancer (0)

Psychosocial interventions (1)

Interventions for reducing anxiety in women undergoing colposcopy

Interventions targeted at women to encourage the uptake of cervical screening

Effects of human papillomavirus (HPV) vaccination programmes on community rates of HPV-related disease and harms from vaccination (protocol stage)

Cytology versus HPV testing for cervical cancer screening in the general population

Collection devices for obtaining cervical cytology samples

Strategies and implementation for pre-malignant changes (7)

Interventions for preventing blood loss during the treatment of cervical intraepithelial neoplasia

Immediate referral to colposcopy versus cytological surveillance for minor cervical cytological abnormalities in the absence of HPV test

Surgery for cervical intraepithelial neoplasia

Pain relief for women with cervical intraepithelial neoplasia undergoing colposcopy treatment

Antibiotics for infection prevention after excision of the cervical transformation zone

Non-steroidal anti-inflammatory agents to induce regression and prevent the progression of cervical intraepithelial neoplasia

Retinoids for preventing the progression of cervical intra-epithelial neoplasia

Initial management of invasive cancer (18)

Follow-up strategies for women with endometrial cancer after primary treatment (protocol stage)

Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early-stage cervical cancer

Follow-up protocols for women with cervical cancer after primary treatment

Radiotherapy (1)

Radiotherapy and chemoradiation after surgery for early cervical cancer

Early surgical treatment versus observational management for cervical intraepithelial neoplasia 2 (CIN2) (protocol stage)

Laparoscopically assisted radical vaginal hysterectomy versus radical abdominal hysterectomy for the treatment of early cervical cancer

Nerve-sparing radical hysterectomy compared to standard radical hysterectomy for women with early stage cervical cancer (stage Ia2 to IIa)

Simple versus radical hysterectomy with pelvic lymphadenectomy for women with stage IA2-IB1 cervical cancer (protocol stage)

Type II or type III radical hysterectomy compared to chemoradiotherapy as a primary intervention for stage IB2 cervical cancer

Surgical treatment of stage IA2 cervical cancer

Combined modality therapy (6)

Concomitant chemotherapy and radiation therapy for cancer of the uterine cervix

Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: individual patient data meta-analysis

Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer

Primary surgery versus primary radiotherapy with or without chemotherapy for early adenocarcinoma of the uterine cervix

Concomitant hydroxyurea plus radiotherapy versus radiotherapy for carcinoma of the uterine cervix

Vascular endothelial growth factor (VEGF) inhibitors for the treatment of metastatic and recurrent cervical cancer (protocol stage)

Neoadjuvant chemotherapy (1)

Neoadjuvant chemotherapy for locally advanced cervix cancer

Adjuvant chemotherapy (1)

Adjuvant platinum-based chemotherapy for early stage cervical cancer

Management of advanced disease (11)

Combined modality therapy (0)

Radiotherapy (4)

Combined use of hyperthermia and (chemo)radiation therapy for treating locally advanced cervix carcinoma

Extended-field radiotherapy for locally advanced cervical cancer

High dose rate versus low dose rate intracavity brachytherapy for locally advanced uterine cervix cancer

Neoadjuvant chemotherapy and surgery versus chemoradiotherapy for locally advanced cervical cancer (protocol stage)

Chemotherapy (3)

Adjuvant chemotherapy after concurrent chemoradiation for locally advanced cervical cancer

Chemotherapy for metastatic and recurrent cervical cancer

Neoadjuvant chemotherapy and surgery versus chemoradiotherapy for locally advanced cervical cancer (protocol stage)

Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage (2019) IB3/II cervical cancer

Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer

Neoadjuvant chemotherapy and surgery versus chemoradiotherapy for locally advanced cervical cancer (protocol stage)

Pre-treatment surgical para-aortic lymph node assessment in locally advanced cervical cancer

Management of uncommon histologies (2)

Prophylaxis for Pneumocystis pneumonia (PCP) in non-HIV immunocompromised patients

Palliative interventions for controlling vaginal bleeding in advanced cervical cancer

CANCER OF THE OVARY (44)

Positron emission tomography (PET) and magnetic resonance imaging (MRI) for assessing tumour resectability in advanced epithelial ovarian/fallopian tube/primary peritoneal cancer

Laparoscopy for diagnosing resectability of disease in women with advanced ovarian cancer

Menopausal status, ultrasound and biomarker tests in combination for the diagnosis of ovarian cancer in symptomatic women

Interventions to improve psychosocial well-being in female BRCA-mutation carriers following risk-reducing surgery

Risk-reducing bilateral salpingo-oophorectomy in women with BRCA1 or BRCA2 mutations

Impact of epithelial ovarian cancer screening on patient-relevant outcomes in average-risk postmenopausal women (protocol stage)

Intraoperative frozen section analysis for the diagnosis of early stage ovarian cancer in suspicious pelvic masses

Initial management and follow-up (15)

Immunotherapy (0)

Laparoscopy versus laparotomy for FIGO stage I ovarian cancer

Lymph node dissection (lymphadenectomy) for presumed early stage epithelial ovarian cancer (protocol stage)

Ultra-radical (extensive) surgery versus standard surgery for the primary cytoreduction of advanced epithelial ovarian cancer

Radiotherapy (1)

Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma

Chemotherapy (7)

Pegylated liposomal doxorubicin for first-line treatment of epithelial ovarian cancer

Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma

Weekly versus tri-weekly paclitaxel with carboplatin for first-line treatment in women with epithelial ovarian cancer

Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer

Maintenance chemotherapy for ovarian cancer

Adjuvant (post-surgery) chemotherapy for early stage epithelial ovarian cancer

Topotecan for ovarian cancer

Hormonal therapy (1)

Antigen-specific active immunotherapy for ovarian cancer

Combined modality therapy (2)

Effectiveness of different treatment modalities for the management of adult-onset granulosa cell tumours of the ovary (primary and recurrent)

Interventions for the treatment of borderline ovarian tumours

Evaluation of follow-up strategies for patients with epithelial ovarian cancer following completion of primary treatment

Management of advanced disease (22)

Optimal primary surgical treatment for advanced epithelial ovarian cancer

Effectiveness of tranexamic acid in reducing blood loss during cytoreductive surgery for advanced ovarian cancer

Interval debulking surgery for advanced epithelial ovarian cancer

Minimally invasive surgery (robotic or laparoscopic) versus laparotomy for advanced ovarian cancer (protocol stage)

Cytoreductive surgery plus chemotherapy versus chemotherapy alone for recurrent epithelial ovarian cancer

Surgical cytoreduction for recurrent epithelial ovarian cancer

Radiotherapy (0)

Chemotherapy (10)

Pegylated liposomal doxorubicin for relapsed epithelial ovarian cancer

Angiogenesis inhibitors for the treatment of ovarian cancer

Chemotherapy for malignant germ cell ovarian cancer in adult patients with early stage, advanced and recurrent disease

Epidermal growth factor receptor blockers for the treatment of ovarian cancer

Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer

Gemcitabine for platinum-resistant or recurrent ovarian cancer (protocol stage)

Taxane monotherapy regimens for the treatment of recurrent epithelial ovarian cancer

Interferon after surgery for women with advanced (Stage II-IV) epithelial ovarian cancer

Oral etoposide for treatment and/or maintenance treatment of recurrent epithelial ovarian cancer (protocol stage)

Chemotherapy for advanced ovarian cancer

Hormonal therapy (4)

Hormone replacement therapy after surgery for epithelial ovarian cancer

Tamoxifen for relapse of ovarian cancer

Tamoxifen and aromatase inhibitors for relapse of tubo-ovarian high-grade serous cancer (protocol stage)

Luteinising hormone releasing hormone (LHRH) agonists for the treatment of relapsed epithelial ovarian cancer

Combined modality therapy (2)

Neoadjuvant chemotherapy before surgery versus surgery followed by chemotherapy for initial treatment in advanced ovarian epithelial cancer

Impact of residual disease as a prognostic factor for survival in women with advanced epithelial ovarian cancer after primary surgery

CANCER OF THE UTERINE BODY (22)

Sentinel node biopsy for diagnosis of lymph node involvement in endometrial cancer

Cytology for the diagnosis of endometrial cancer in symptomatic women (protocol stage)

Health education interventions to promote early presentation and referral for women with symptoms of endometrial cancer

Impact of ovarian preservation on survival for women with endometrial carcinoma (protocol stage)

Interventions to improve insulin resistance for the prevention of endometrial cancer (protocol stage)

Risk of endometrial cancer in women treated with ovary-stimulating drugs for subfertility

Prognostic models for predicting recurrence and survival in women with endometrial cancer (protocol stage)

Screening tests for endometrial cancer in the general population (protocol stage)

Initial management (9)

Interventions for weight reduction in obesity to improve survival in women with endometrial cancer

Hormone therapy (1)

Hormone replacement therapy for women previously treated for endometrial cancer

Mixed modalities (0)

Fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer (protocol stage)

Laparoscopy versus laparotomy for the management of early stage endometrial cancer

Lymphadenectomy for the management of endometrial cancer

Radiotherapy (1)

Adjuvant radiotherapy for stage I endometrial cancer

Chemotherapy (3)

Adjuvant chemotherapy for advanced endometrial cancer

Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma

Adjuvant chemotherapy for endometrial cancer after hysterectomy

Management of advanced disease (4)

Hormonal therapy (3)

PI3K/AKT/mTOR inhibitors for advanced or recurrent endometrial cancer

Adjuvant progestagens for endometrial cancer

Hormonal therapy in advanced or recurrent endometrial cancer

Mixed modalities (1)

Adjuvant treatment after hysterectomy for uterine leiomyosarcoma (protocol stage)

Chemotherapy (1)

Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma

Management of uncommon histologies (0)

CANCER OF THE VULVA (9)

Management of initial and advanced disease (5)

Sentinel node assessment for diagnosis of groin lymph node involvement in vulval cancer

Surgical interventions for early squamous cell carcinoma of the vulva

Radiotherapy (2)

Adjuvant radiotherapy for inguinal lymph node metastases following surgery for vulval cancer (protocol stage)

Primary groin irradiation versus primary groin surgery for early vulvar cancer

Chemotherapy (0)

Combined modality therapy (1)

Chemoradiation for advanced primary vulval cancer

Strategies and implementation for pre-malignant changes (4)

Medical interventions for high-grade vulval intraepithelial neoplasia

Surgical interventions for high-grade vulval intraepithelial neoplasia

Medical and surgical interventions for the treatment of usual-type vulval intraepithelial neoplasia

Interventions for the treatment of Paget's disease of the vulva

CANCER OF THE VAGINA (0)

Management of vaginal intraepithelial neoplasia (VAIN) (0)

Management of invasive cancer (0)

Radiotherapy (0)

Chemotherapy (0)

Combined modality therapy (0)

NEURO-ONCOLOGY (38)

Early versus delayed postoperative radiotherapy for treatment of low-grade gliomas

Biopsy versus resection for high-grade glioma

Interval brain imaging for adults with cerebral glioma

Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma

Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas

Anti-epidermal growth factor receptor therapy for glioblastoma in adults

Anti-angiogenic therapy for high-grade glioma

First-line treatments for people with single or multiple brain metastases (protocol stage)

Magnetic resonance perfusion for differentiating low-grade from high-grade gliomas at first presentation

Interventions to reduce the time to diagnosis of brain tumours

Intraoperative imaging technology to maximise extent of resection for glioma: a network meta-analysis

Intraoperative imaging technology to maximise extent of resection for glioma

Image guided surgery for the resection of brain tumours

Immune checkpoint blockade for glioma (protocol stage)

Immunotherapy for intracranial metastatic melanoma (protocol stage)

Early palliative interventions for improving outcomes in people with a primary malignant brain tumour and their carers

Chemotherapy for high-grade glioma

Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation

Interventions for the management of fatigue in adults with a primary brain tumour

Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery

Interventions to help support caregivers of people with a brain or spinal cord tumour

Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases

Ketogenic diet for primary brain and spinal cord tumours (protocol stage)

Long-term neurocognitive and other side effects of radiotherapy, with or without chemotherapy, for glioma

Procarbazine, lomustine and vincristine for recurrent high-grade glioma

Pharmacological treatment of depression in people with a primary brain tumour

Protons versus photons for the treatment of chordoma

External beam radiation dose escalation for high grade glioma

Surgical resection and whole brain radiation therapy versus whole brain radiation therapy alone for single brain metastases

Surgery versus stereotactic radiotherapy for people with single or solitary brain metastasis

Biopsy versus resection for the management of low-grade gliomas

Temozolomide for high grade glioma

Surgery or radiosurgery plus whole brain radiotherapy versus surgery or radiosurgery alone for brain metastases

Chemotherapy wafers for high grade glioma

Treatment of newly diagnosed glioblastoma in the elderly: a network meta-analysis

Treatment options for progression or recurrence of glioblastoma: a network meta-analysis

Prognostic value of test(s) for O6-methylguanine–DNA methyltransferase (MGMT) promoter methylation for predicting overall survival in people with glioblastoma treated with temozolomide

Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases

SURGICAL TECHNIQUES FOR GYNAECOLOGICAL CANCER (2)

Exenterative surgery for recurrent gynaecological malignancies

Robot-assisted surgery in gynaecology

TROPHOBLASTIC TUMOURS (5)

Prevention- management of hydatidiform mole (0)

Management of invasive cancer (5)

Fertility-sparing, surgical interventions for low-risk, non-metastatic gestational trophoblastic neoplasia (protocol stage)

Radiotherapy (0)

Chemotherapy (4)

Chemotherapy for resistant or recurrent gestational trophoblastic neoplasia

Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour

First-line chemotherapy in low-risk gestational trophoblastic neoplasia

Prophylactic chemotherapy for hydatidiform mole to prevent gestational trophoblastic neoplasia

CANCER OF THE FALLOPIAN TUBE (0)

Management of initial and advanced disease (0)

MISCELLANEOUS GYNAECOLOGICAL CANCER TOPICS (16)

Gestational trophoblastic neoplasia (3)

Chemotherapy for resistant or recurrent gestational trophoblastic neoplasia

First-line chemotherapy in low-risk gestational trophoblastic neoplasia

Prophylactic chemotherapy for hydatidiform mole to prevent gestational trophoblastic neoplasia

Infertility and gynaecological cancer (3)

Fertility and early pregnancy outcomes after conservative treatment for cervical intraepithelial neoplasia

Risk of ovarian cancer in women treated with ovarian stimulating drugs for infertility

Obstetric outcomes after conservative treatment for cervical intraepithelial lesions and early invasive disease

Management of service providers of gynaecological cancer (3)

Patient-reported outcome measures for follow-up after gynaecological cancer treatment

Centralisation of services for gynaecological cancer

Perioperative enhanced recovery programmes for women with gynaecological cancers

Treatment of postoperative morbidities (2)

Retroperitoneal drainage versus no drainage after pelvic lymphadenectomy for the prevention of lymphocyst formation in women with gynaecological malignancies

Perioperative nutrition interventions for women with ovarian cancer

Treatment of symptoms of advanced gynaecological cancer (2)

Management of drainage for malignant ascites in gynaecological cancer

Palliative surgery versus medical management for bowel obstruction in ovarian cancer

Tumour markers in gynaecological cancer (0)

Psychosexual dysfunction due to treatment for cancer (3)

Interventions for psychosexual dysfunction in women treated for gynaecological malignancy

Interventions to improve psychosexual function in women treated for gynaecological cancers (protocol stage)

Vaginal dilator therapy for women receiving pelvic radiotherapy

'ORPHAN' TOPICS CURRENTLY BEING ADDRESSED (88)

Soft tissue sarcoma (5)

Doxorubicin-based chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft tissue sarcoma

Adjuvant chemotherapy for localised resectable soft tissue sarcoma in adults

First- and second-line systemic treatments for metastatic and locally advanced soft tissue sarcomas in adults (protocol stage)

Autologous hematopoietic stem cell transplantation following high-dose chemotherapy for nonrhabdomyosarcoma soft tissue sarcomas

Intralesional treatment versus wide resection for central low-grade chondrosarcoma of the long bones

Infections in neutropenic cancer patients (23)

Prophylaxis for Pneumocystis pneumonia (PCP) in non-HIV immunocompromised patients

Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy

Antifungal therapy in infants and children with proven, probable or suspected invasive fungal infections

Dexrazoxane for preventing or reducing cardiotoxicity in adults and children with cancer receiving anthracyclines

Beta-lactam versus beta-lactam-aminoglycoside combination therapy in cancer patients with neutropenia

Colony-stimulating factors for chemotherapy-induced febrile neutropenia

Cardioprotective interventions for cancer patients receiving anthracyclines

Influenza vaccines in immunosuppressed adults with cancer

Voriconazole versus amphotericin B or fluconazole in cancer patients with neutropenia

(1→3)-β-D-glucan testing for the detection of invasive fungal infections in immunocompromised or critically ill people

Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients

Outpatient treatment for people with cancer who develop a low-risk febrile neutropaenic event

Pre-emptive antifungal therapy versus empirical antifungal therapy for febrile neutropenia in people with cancer

Nystatin prophylaxis and treatment in severely immunodepressed patients

Amphotericin B versus fluconazole for controlling fungal infections in neutropenic cancer patients

Amphotericin B lipid soluble formulations versus amphotericin B in cancer patients with neutropenia

Routine versus selective antifungal administration for control of fungal infections in patients with cancer

Prophylactic antibiotics for preventing gram-positive infections associated with long-term central venous catheters in adults and children receiving treatment for cancer

Anti-pseudomonal beta-lactams for the initial, empirical, treatment of febrile neutropenia: comparison of beta-lactams

Empirical antibiotics targeting gram-positive bacteria for the treatment of febrile neutropenic patients with cancer

Early discontinuation of antibiotics for febrile neutropenia versus continuation until neutropenia resolution in people with cancer

Granulocyte transfusions for preventing infections in people with neutropenia or neutrophil dysfunction

Granulocyte transfusions for treating infections in people with neutropenia or neutrophil dysfunction

Drug therapies for cancers of similar histological type (4)

Chemotherapy for thymic carcinoma and advanced thymoma in adults

Short versus long duration infusions of paclitaxel for any advanced adenocarcinoma

Next-generation sequencing for guiding matched targeted therapies in people with relapsed or metastatic cancer (protocol stage)

Site-speciﬁc chemotherapy based on gene expression proﬁling versus empirical chemotherapy for people with cancer of unknown primary site (protocol stage)

Enzyme therapy (0)

Complementary therapies for cancer (9)

(Reishi mushroom) for cancer treatment

Ginseng for improving the quality of life in people with cancer (protocol stage)

Green tea (Camellia sinensis) for the prevention of cancer

Laetrile treatment for cancer

Mistletoe extracts for cancer treatment (protocol stage)

Mistletoe therapy in oncology

Moxibustion for alleviating side effects of chemotherapy or radiotherapy in people with cancer

Selenium for preventing cancer

Thymic peptides for treatment of cancer patients

Supportive interventions for cancer patients (27)

Acupuncture for insomnia in people with cancer (protocol stage)

Antidepressants for the treatment of depression in people with cancer

Exercise interventions on health-related quality of life for cancer survivors

Exercise interventions on health-related quality of life for people with cancer during active treatment

Music interventions for improving psychological and physical outcomes in people with cancer

Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy

Cognitive behavioural therapy for insomnia in people with cancer (protocol stage)

Couple-based interventions for improving dyadic adjustment in people with cancer and their spousal partners (protocol stage)

Dance/movement therapy for improving psychological and physical outcomes in cancer patients

Dietary interventions for adult cancer survivors

Nutritional interventions for reducing gastrointestinal toxicity in adults undergoing radical pelvic radiotherapy

Effects of different weight loss programmes on oncological outcomes following curative resection of digestive tract cancers (protocol stage)

Electric fans for reducing adverse health impacts in heatwaves

Exercise interventions for adults with cancer receiving radiation therapy alone (protocol stage)

Exercise interventions for people undergoing multimodal cancer treatment that includes surgery

Home parenteral nutrition for people with inoperable malignant bowel obstruction

Psychosocial interventions to improve quality of life and emotional wellbeing for recently diagnosed cancer patients

Non-pharmacological interventions for cognitive impairment due to systemic cancer treatment

Interventions for promoting habitual exercise in people living with and beyond cancer

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic cancers

Multidimensional rehabilitation programmes for adult cancer survivors

Non-surgical interventions for late radiation cystitis in patients who have received radical radiotherapy to the pelvis

Non-surgical interventions for late rectal problems (proctopathy) of radiotherapy in people who have received radiotherapy to the pelvis

Spiritual and religious interventions for adults with cancer and their carers: an overview of systematic reviews (protocol stage)

Systematic screening and assessment of psychosocial well-being and care needs of people with cancer

Telephone interventions for symptom management in adults with cancer

Interventions for the physical aspects of sexual dysfunction in women following pelvic radiotherapy

Training interventions for cancer carers and professionals (1)

Communication skills training for healthcare professionals working with people who have cancer

Treatment of miscellaneous conditions in cancer (12)

Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised people

Oral anticoagulation in people with cancer who have no therapeutic or prophylactic indication for anticoagulation

Anticoagulation for the initial treatment of venous thromboembolism in people with cancer

Anticoagulation for the long-term treatment of venous thromboembolism in people with cancer

Anticoagulation for perioperative thromboprophylaxis in people with cancer

Antithrombotic therapy for ambulatory patients with multiple myeloma receiving immunomodulatory agents

Anticoagulation for people with cancer and central venous catheters

Pharmacological interventions for the prevention of insufficiency fractures and avascular necrosis associated with pelvic radiotherapy in adults

Parenteral anticoagulation in ambulatory patients with cancer

Probiotics for the prevention or treatment of chemotherapy- or radiotherapy-related diarrhoea in people with cancer

Thalidomide for managing cancer cachexia

Treatment for gastrointestinal and pancreatic neuroendocrine tumours: a network meta-analysis

Techniques to modulate the effects of chemotherapy and/or radiotherapy (7)

Different anthracycline derivates for reducing cardiotoxicity in cancer patients

Different dosage schedules for reducing cardiotoxicity in people with cancer receiving anthracycline chemotherapy

Adjuvant gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in premenopausal women

Hyperbaric oxygenation for tumour sensitisation to radiotherapy

Hyperbaric oxygen therapy for late radiation tissue injury

Pentoxifylline and vitamin E alone or in combination for preventing and treating side effects of radiation therapy and concomitant chemoradiotherapy (protocol stage)

Site-speciﬁc chemotherapy based on gene expression proﬁling versus empirical chemotherapy for people with cancer of unknown primary site (protocol stage)

New and Updated (in the latest issue of the CLib):