Our Reviews

Our Reviews

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CANCER OF THE UTERINE CERVIX (47)
Diagnosis (5)
Follow-up strategies after treatment (large loop excision of the transformation zone (LLETZ)) for cervical intraepithelial neoplasia (CIN): Impact of human papillomavirus (HPV) test
Human papillomavirus testing versus repeat cytology for triage of minor cytological cervical lesions
Vascular endothelial growth factor (VEGF) targeting therapy for persistent, recurrent, or metastatic cervical cancer
Low cost versus other screening tests to detect cervical cancer or precancer in developing countries (protocol stage)
Sentinel node biopsy for diagnosis of pelvic lymph node involvement in early stage cervical cancer (protocol stage)
Prevention (3)
Comparison of different human papillomavirus (HPV) vaccine types and dose schedules for prevention of HPV-related disease in females and males
Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors
Interventions for encouraging sexual behaviours intended to prevent cervical cancer
Immunisation strategies (HPV) to prevent cervical cancer (0)
Psychosocial interventions (1)
Interventions for reducing anxiety in women undergoing colposcopy
Screening (3)
Cytology versus HPV testing for cervical cancer screening in the general population
Interventions targeted at women to encourage the uptake of cervical screening
Collection devices for obtaining cervical cytology samples
Strategies and implementation for pre-malignant changes (7)
Interventions for preventing blood loss during the treatment of cervical intraepithelial neoplasia
Immediate referral to colposcopy versus cytological surveillance for minor cervical cytological abnormalities in the absence of HPV test
Surgery for cervical intraepithelial neoplasia
Pain relief for women with cervical intraepithelial neoplasia undergoing colposcopy treatment
Antibiotics for infection prevention after excision of the cervical transformation zone
Non-steroidal anti-inflammatory agents to induce regression and prevent the progression of cervical intraepithelial neoplasia
Retinoids for preventing the progression of cervical intra-epithelial neoplasia
Initial management of invasive cancer (13)
Follow up (2)
Follow-up strategies for women with endometrial cancer after primary treatment (protocol stage)
Follow-up protocols for women with cervical cancer after primary treatment
Radiotherapy (0)
Surgery (3)
Laparoscopically assisted radical vaginal hysterectomy versus radical abdominal hysterectomy for the treatment of early cervical cancer
Type II or type III radical hysterectomy compared to chemoradiotherapy as a primary intervention for stage IB2 cervical cancer
Surgical treatment of stage IA2 cervical cancer
Combined modality therapy (6)
Concomitant chemotherapy and radiation therapy for cancer of the uterine cervix
Reducing uncertainties about the effects of chemoradiotherapy for cervical cancer: individual patient data meta-analysis
Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer
Primary surgery versus primary radiotherapy with or without chemotherapy for early adenocarcinoma of the uterine cervix
Concomitant hydroxyurea plus radiotherapy versus radiotherapy for carcinoma of the uterine cervix
Vascular endothelial growth factor (VEGF) inhibitors for the treatment of metastatic and recurrent cervical cancer (protocol stage)
Neoadjuvant chemotherapy (1)
Neoadjuvant chemotherapy for locally advanced cervix cancer
Adjuvant chemotherapy (1)
Adjuvant platinum-based chemotherapy for early stage cervical cancer
Management of advanced disease (13)
Radiotherapy (4)
Combined use of hyperthermia and radiation therapy for treating locally advanced cervix carcinoma
Extended-field radiotherapy for locally advanced cervical cancer
High dose rate versus low dose rate intracavity brachytherapy for locally advanced uterine cervix cancer
Radiotherapy and chemoradiation after surgery for early cervical cancer
Chemotherapy (2)
Adjuvant chemotherapy after concurrent chemoradiation for locally advanced cervical cancer
Chemotherapy for metastatic and recurrent cervical cancer
Surgery (7)
Debulking hysterectomy followed by chemoradiotherapy versus chemoradiotherapy for FIGO stage IB2/II cervical cancer (protocol stage)
Early surgical treatment versus observational management for cervical intraepithelial neoplasia 2 (CIN2) (protocol stage)
Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer
Nerve-sparing radical hysterectomy compared to standard radical hysterectomy for women with early stage cervical cancer (stage Ia2 to IIa)
Postoperative interventions for preventing bladder dysfunction after radical hysterectomy in women with early-stage cervical cancer
Simple versus radical hysterectomy with pelvic lymphadenectomy for women with stage IA2-IB1 cervical cancer (protocol stage)
Pre-treatment surgical para-aortic lymph node assessment in locally advanced cervical cancer
Management of uncommon histologies (2)
Prophylaxis for Pneumocystis pneumonia (PCP) in non-HIV immunocompromised patients
Palliative interventions for controlling vaginal bleeding in advanced cervical cancer
CANCER OF THE OVARY (43)
Diagnosis (3)
Positron emission tomography (PET) and magnetic resonance imaging (MRI) for assessing tumour resectability in advanced epithelial ovarian/fallopian tube/primary peritoneal cancer
Laparoscopy for diagnosing resectability of disease in women with advanced ovarian cancer
Symptoms, ultrasound imaging and biochemical markers alone or in combination for the diagnosis of ovarian cancer in women with symptoms suspicious of ovarian cancer (protocol stage)
Prevention (2)
Interventions to improve psychosocial well-being in female BRCA-mutation carriers following risk-reducing surgery
Risk-reducing bilateral salpingo-oophorectomy in women with BRCA1 or BRCA2 mutations
Screening (2)
Impact of epithelial ovarian cancer screening on patient-relevant outcomes in average-risk postmenopausal women (protocol stage)
Intraoperative frozen section analysis for the diagnosis of early stage ovarian cancer in suspicious pelvic masses
Initial management and follow-up (15)
Surgery (3)
Laparoscopy versus laparotomy for FIGO stage I ovarian cancer
Lymph node dissection (lymphadenectomy) for presumed early stage epithelial ovarian cancer (protocol stage)
Ultra-radical (extensive) surgery versus standard surgery for the primary cytoreduction of advanced epithelial ovarian cancer
Radiotherapy (1)
Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma
Chemotherapy (7)
Pegylated liposomal doxorubicin for first-line treatment of epithelial ovarian cancer
Chemotherapy and/or radiotherapy in combination with surgery for ovarian carcinosarcoma
Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer
Maintenance chemotherapy for ovarian cancer
Adjuvant (post-surgery) chemotherapy for early stage epithelial ovarian cancer
Topotecan for ovarian cancer
Weekly versus tri-weekly paclitaxel with carboplatin for first-line treatment in women with ovarian cancer (protocol stage)
Hormonal therapy (1)
Antigen-specific active immunotherapy for ovarian cancer
Combined modality therapy (2)
Effectiveness of different treatment modalities for the management of adult-onset granulosa cell tumours of the ovary (primary and recurrent)
Interventions for the treatment of borderline ovarian tumours
Follow-up (1)
Evaluation of follow-up strategies for patients with epithelial ovarian cancer following completion of primary treatment
Management of advanced disease (21)
Surgery (6)
Optimal primary surgical treatment for advanced epithelial ovarian cancer
Effectiveness of tranexamic acid in reducing blood loss during cytoreductive surgery for advanced ovarian cancer
Interval debulking surgery for advanced epithelial ovarian cancer
Minimally invasive surgery (robotic or laparoscopic) versus laparotomy for advanced ovarian cancer (protocol stage)
Cytoreductive surgery plus chemotherapy versus chemotherapy alone for recurrent epithelial ovarian cancer
Surgical cytoreduction for recurrent epithelial ovarian cancer
Radiotherapy (0)
Chemotherapy (10)
Pegylated liposomal doxorubicin for relapsed epithelial ovarian cancer
Angiogenesis inhibitors for the treatment of ovarian cancer
Chemotherapy for malignant germ cell ovarian cancer in adult patients with early stage, advanced and recurrent disease
Epidermal growth factor receptor blockers for the treatment of ovarian cancer
Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer
Gemcitabine for platinum-resistant or recurrent ovarian cancer (protocol stage)
Interferon after surgery for women with advanced (Stage II-IV) epithelial ovarian cancer
Oral etoposide for treatment and/or maintenance treatment of recurrent epithelial ovarian cancer (protocol stage)
Chemotherapy for advanced ovarian cancer
Taxane monotherapy regimens for the treatment of recurrent epithelial ovarian cancer (protocol stage)
Hormonal therapy (4)
Hormone replacement therapy after surgery for epithelial ovarian cancer
Tamoxifen for relapse of ovarian cancer
Tamoxifen and aromatase inhibitors for relapse of tubo-ovarian high-grade serous cancer (protocol stage)
Luteinising hormone releasing hormone (LHRH) agonists for the treatment of relapsed epithelial ovarian cancer
Combined modality therapy (1)
Chemotherapy versus surgery for initial treatment in advanced ovarian epithelial cancer
CANCER OF THE UTERINE BODY (20)
Diagnosis (3)
Sentinel node biopsy for diagnosis of lymph node involvement in endometrial cancer
Cytology for the diagnosis of endometrial cancer in symptomatic women (protocol stage)
Health education interventions to promote early presentation and referral for women with symptoms of endometrial cancer
Prevention (2)
Interventions to improve insulin resistance for the prevention of endometrial cancer (protocol stage)
Risk of endometrial cancer in women treated with ovary-stimulating drugs for subfertility
Prognosis (0)
Screening (1)
Screening tests for endometrial cancer in the general population (protocol stage)
Initial management (9)
Follow-up (1)
Interventions for weight reduction in obesity to improve survival in women with endometrial cancer
Hormone therapy (1)
Hormone replacement therapy for women previously treated for endometrial cancer
Mixed modalities (0)
Surgery (3)
Fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer (protocol stage)
Laparoscopy versus laparotomy for the management of early stage endometrial cancer
Lymphadenectomy for the management of endometrial cancer
Radiotherapy (1)
Adjuvant radiotherapy for stage I endometrial cancer
Chemotherapy (3)
Adjuvant chemotherapy for advanced endometrial cancer
Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma
Adjuvant chemotherapy for endometrial cancer after hysterectomy
Management of advanced disease (4)
Hormonal therapy (3)
PI3K/AKT/mTOR inhibitors for advanced or recurrent endometrial cancer
Adjuvant progestagens for endometrial cancer
Hormonal therapy in advanced or recurrent endometrial cancer
Mixed modalities (1)
Adjuvant treatment after hysterectomy for uterine leiomyosarcoma (protocol stage)
Chemotherapy (1)
Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma
Management of uncommon histologies (0)
CANCER OF THE VULVA (9)
Management of initial and advanced disease (5)
Surgery (2)
Sentinel node assessment for diagnosis of groin lymph node involvement in vulval cancer
Surgical interventions for early squamous cell carcinoma of the vulva
Radiotherapy (2)
Adjuvant radiotherapy for inguinal lymph node metastases following surgery for vulval cancer (protocol stage)
Primary groin irradiation versus primary groin surgery for early vulvar cancer
Chemotherapy (0)
Combined modality therapy (1)
Chemoradiation for advanced primary vulval cancer
Strategies and implementation for pre-malignant changes (4)
Medical interventions for high-grade vulval intraepithelial neoplasia
Surgical interventions for high-grade vulval intraepithelial neoplasia
Medical and surgical interventions for the treatment of usual-type vulval intraepithelial neoplasia
Interventions for the treatment of Paget's disease of the vulva
CANCER OF THE VAGINA (0)
NEURO-ONCOLOGY (38)
Early versus delayed postoperative radiotherapy for treatment of low-grade gliomas
Biopsy versus resection for high-grade glioma
Interval brain imaging for adults with cerebral glioma
Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma (protocol stage)
Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas
Anti-epidermal growth factor receptor therapy for glioblastoma in adults
Anti-angiogenic therapy for high-grade glioma
Early palliative interventions for improving outcomes in people with a primary malignant brain tumour and their carers (protocol stage)
First-line treatments for people with single or multiple brain metastases (protocol stage)
Magnetic resonance perfusion for differentiating low-grade from high-grade gliomas at first presentation
Interventions to reduce the time to diagnosis of brain tumours
Intraoperative imaging technology to maximise extent of resection for glioma
Intraoperative imaging technology to maximise extent of resection for glioma: a network meta-analysis
Image guided surgery for the resection of brain tumours
Immune checkpoint blockade for glioma (protocol stage)
Immunotherapy for intracranial metastatic melanoma (protocol stage)
Chemotherapy for high-grade glioma
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation
Interventions for the management of fatigue in adults with a primary brain tumour
Interventions for the treatment of brain radionecrosis after radiotherapy or radiosurgery
Interventions to help support caregivers of people with a brain or spinal cord tumour
Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases
Ketogenic diet for primary brain and spinal cord tumours (protocol stage)
Long-term neurocognitive and other side effects of radiotherapy, with or without chemotherapy, for glioma
Particles versus photons for the treatment of chordoma (protocol stage)
Procarbazine, lomustine and vincristine for recurrent high-grade glioma
Pharmacological treatment of depression in people with a primary brain tumour
External beam radiation dose escalation for high grade glioma
Surgical resection and whole brain radiation therapy versus whole brain radiation therapy alone for single brain metastases
Surgery versus stereotactic radiotherapy for people with single or solitary brain metastasis
Biopsy versus resection for the management of low-grade gliomas
Temozolomide for high grade glioma
Surgery or radiosurgery plus whole brain radiotherapy versus surgery or radiosurgery alone for brain metastases
Chemotherapy wafers for high grade glioma
Treatment of newly diagnosed glioblastoma in the elderly: a network meta-analysis
Treatment options for progression or recurrence of glioblastoma: a network meta-analysis
Prognostic value of test(s) for O6-methylguanine–DNA methyltransferase (MGMT) promoter methylation for predicting overall survival in people with glioblastoma treated with temozolomide
Whole brain radiotherapy for the treatment of newly diagnosed multiple brain metastases
SURGICAL TECHNIQUES FOR GYNAECOLOGICAL CANCER (2)
Exenterative surgery for recurrent gynaecological malignancies
Robot-assisted surgery in gynaecology
TROPHOBLASTIC TUMOURS (1)
Management of invasive cancer (1)
Chemotherapy (1)
Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour
CANCER OF THE FALLOPIAN TUBE (0)
MISCELLANEOUS GYNAECOLOGICAL CANCER TOPICS (15)
Gestational trophoblastic neoplasia (3)
Chemotherapy for resistant or recurrent gestational trophoblastic neoplasia
First-line chemotherapy in low-risk gestational trophoblastic neoplasia
Prophylactic chemotherapy for hydatidiform mole to prevent gestational trophoblastic neoplasia
Infertility and gynaecological cancer (3)
Fertility and early pregnancy outcomes after conservative treatment for cervical intraepithelial neoplasia
Risk of ovarian cancer in women treated with ovarian stimulating drugs for infertility
Obstetric outcomes after conservative treatment for cervical intraepithelial lesions and early invasive disease
Management of service providers of gynaecological cancer (3)
Patient-reported outcome measures for follow-up after gynaecological cancer treatment
Centralisation of services for gynaecological cancer
Perioperative enhanced recovery programmes for gynaecological cancer patients
Treatment of postoperative morbidities (2)
Retroperitoneal drainage versus no drainage after pelvic lymphadenectomy for the prevention of lymphocyst formation in women with gynaecological malignancies
Perioperative nutrition interventions for women with ovarian cancer
Treatment of symptoms of advanced gynaecological cancer (2)
Management of drainage for malignant ascites in gynaecological cancer
Palliative surgery versus medical management for bowel obstruction in ovarian cancer
Tumour markers in gynaecological cancer (0)
Psychosexual dysfunction due to treatment for cancer (2)
Interventions for psychosexual dysfunction in women treated for gynaecological malignancy
Vaginal dilator therapy for women receiving pelvic radiotherapy
'ORPHAN' TOPICS CURRENTLY BEING ADDRESSED (80)
Soft tissue sarcoma (5)
Doxorubicin-based chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft tissue sarcoma
Adjuvant chemotherapy for localised resectable soft tissue sarcoma in adults
First- and second-line systemic treatments for metastatic and locally advanced soft tissue sarcomas in adults (protocol stage)
Autologous hematopoietic stem cell transplantation following high-dose chemotherapy for nonrhabdomyosarcoma soft tissue sarcomas
Intralesional treatment versus wide resection for central low-grade chondrosarcoma of the long bones
Infections in neutropenic cancer patients (22)
Prophylaxis for Pneumocystis pneumonia (PCP) in non-HIV immunocompromised patients
Prophylactic antibiotics for preventing Gram positive infections associated with long-term central venous catheters in oncology patients
Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy
Antifungal therapy in infants and children with proven, probable or suspected invasive fungal infections
Beta-lactam versus beta-lactam-aminoglycoside combination therapy in cancer patients with neutropenia
Colony-stimulating factors for chemotherapy-induced febrile neutropenia
Cardioprotective interventions for cancer patients receiving anthracyclines
Influenza vaccines in immunosuppressed adults with cancer
Voriconazole versus amphotericin B or fluconazole in cancer patients with neutropenia
(1→3)-β-D-glucan testing for the detection of invasive fungal infections in immunocompromised or critically ill people
Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients
Outpatient treatment for people with cancer who develop a low-risk febrile neutropaenic event
Pre-emptive antifungal therapy versus empirical antifungal therapy for febrile neutropenia in people with cancer (protocol stage)
Nystatin prophylaxis and treatment in severely immunodepressed patients
Amphotericin B versus fluconazole for controlling fungal infections in neutropenic cancer patients
Amphotericin B lipid soluble formulations versus amphotericin B in cancer patients with neutropenia
Routine versus selective antifungal administration for control of fungal infections in patients with cancer
Anti-pseudomonal beta-lactams for the initial, empirical, treatment of febrile neutropenia: comparison of beta-lactams
Empirical antibiotics targeting gram-positive bacteria for the treatment of febrile neutropenic patients with cancer
Early discontinuation of antibiotics for febrile neutropenia versus continuation until neutropenia resolution in people with cancer
Granulocyte transfusions for preventing infections in people with neutropenia or neutrophil dysfunction
Granulocyte transfusions for treating infections in people with neutropenia or neutrophil dysfunction
Drug therapies for cancers of similar histological type (2)
Chemotherapy for thymic carcinoma and advanced thymoma in adults
Short versus long duration infusions of paclitaxel for any advanced adenocarcinoma
Enzyme therapy (0)
Complementary therapies for cancer (9)
(Reishi mushroom) for cancer treatment
Ginseng for improving the quality of life in people with cancer (protocol stage)
Green tea (Camellia sinensis) for the prevention of cancer
Laetrile treatment for cancer
Melatonin in cancer treatment (protocol stage)
Mistletoe therapy in oncology
Moxibustion for alleviating side effects of chemotherapy or radiotherapy in people with cancer
Selenium for preventing cancer
Thymic peptides for treatment of cancer patients
Supportive interventions for cancer patients (24)
Antidepressants for the treatment of depression in people with cancer
Exercise interventions on health-related quality of life for cancer survivors
Exercise interventions on health-related quality of life for people with cancer during active treatment
Music interventions for improving psychological and physical outcomes in cancer patients
Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy
Couple-based interventions for improving dyadic adjustment in people with cancer and their spousal partners (protocol stage)
Dance/movement therapy for improving psychological and physical outcomes in cancer patients
Dietary interventions for adult cancer survivors
Nutritional interventions for reducing gastrointestinal toxicity in adults undergoing radical pelvic radiotherapy
Electric fans for reducing adverse health impacts in heatwaves
Exercise interventions for adults with cancer receiving radiation therapy alone (protocol stage)
Exercise interventions for people undergoing multimodal cancer treatment that includes surgery
Home parenteral nutrition for people with inoperable malignant bowel obstruction
Psychosocial interventions to improve quality of life and emotional wellbeing for recently diagnosed cancer patients
Non-pharmacological interventions for cognitive impairment due to systemic cancer treatment
Interventions for promoting habitual exercise in people living with and beyond cancer
Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic cancers
Multidimensional rehabilitation programmes for adult cancer survivors
Non-surgical interventions for late rectal problems (proctopathy) of radiotherapy in people who have received radiotherapy to the pelvis
Non-surgical interventions for late radiation cystitis in patients who have received radical radiotherapy to the pelvis
Spiritual and religious interventions for adults with cancer and their carers: an overview of systematic reviews (protocol stage)
Systematic screening and assessment of psychosocial well-being and care needs of people with cancer
Telephone interventions for symptom management in adults with cancer
Interventions for the physical aspects of sexual dysfunction in women following pelvic radiotherapy
Training interventions for cancer carers and professionals (1)
Communication skills training for healthcare professionals working with people who have cancer
Treatment of miscellaneous conditions in cancer (11)
Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised people
Anticoagulation for the initial treatment of venous thromboembolism in people with cancer
Anticoagulation for the long-term treatment of venous thromboembolism in people with cancer
Anticoagulation for perioperative thromboprophylaxis in people with cancer
Anticoagulation for people with cancer and central venous catheters
Pharmacological interventions for the prevention of insufficiency fractures and avascular necrosis associated with pelvic radiotherapy in adults
Parenteral anticoagulation in ambulatory patients with cancer
Probiotics for the prevention or treatment of chemotherapy- or radiotherapy-related diarrhoea in people with cancer
Oral anticoagulation in people with cancer who have no therapeutic or prophylactic indication for anticoagulation
Thalidomide for managing cancer cachexia
Treatment for gastrointestinal and pancreatic neuroendocrine tumours: a network meta-analysis (protocol stage)
Techniques to modulate the effects of chemotherapy and/or radiotherapy (6)
Different anthracycline derivates for reducing cardiotoxicity in cancer patients
Different dosage schedules for reducing cardiotoxicity in people with cancer receiving anthracycline chemotherapy
Adjuvant gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in premenopausal women
Hyperbaric oxygenation for tumour sensitisation to radiotherapy
Hyperbaric oxygen therapy for late radiation tissue injury
Pentoxifylline and vitamin E alone or in combination for preventing and treating side effects of radiation therapy and concomitant chemoradiotherapy (protocol stage)